Progesterone (Micronized)
genericFDA-approved; generic micronized progesterone available
Est. Cost
$15 - $60/mo
Micronized progesterone is a key component of hormone replacement therapy for women who have an intact uterus. When estrogen is taken alone (without progesterone), it can cause the uterine lining to thicken, which may increase the risk of endometrial hyperplasia or cancer. Progesterone counteracts this effect by promoting regular shedding of the lining. Micronized progesterone is considered bioidentical because its molecular structure is identical to the progesterone produced naturally by the ovaries. It is generally well-tolerated and may also have mild sedative properties that can help with sleep when taken at bedtime.
Dosage Format
Typically 100mg or 200mg taken orally at bedtime. Dosing schedule varies — may be taken daily (continuous) or for 12-14 days per month (cyclical) depending on the treatment approach and whether estrogen is taken continuously. Always taken as directed by a provider.
Type
Generic
Who to discuss it with
Women with an intact uterus who take systemic estrogen and need progesterone to protect the uterine lining
Key distinction
Micronized progesterone is chemically identical to the progesterone the body naturally produces and is generally considered to have a more favorable safety profile compared to synthetic progestins.
Where to Get Progesterone (Micronized)
Provider listings related to progesterone (micronized). Confirm the exact formulation, current availability, and full price directly.
Evernow
Prescribed alongside estradiol as part of combined HRT plans. Sent to your pharmacy where insurance may cover the cost.
Medication cost varies (insurance may apply)
Alloy Health
Progesterone capsules included in applicable treatment plans with free quarterly delivery.
Included in HRT subscription
Winona
Available as oral capsules. Often prescribed alongside estrogen in combination plans.
From ~$45/mo (as part of oral HRT plan)
Hers
Progesterone included in menopause treatment plans for women with an intact uterus.
Included in HRT subscription plans
Noom
Progesterone pill included in both cream and patch HRTRx plans alongside estrogen therapy.
Included in HRTRx plans
How Progesterone (Micronized) Works
Progesterone works by binding to progesterone receptors in the uterine lining, counteracting the growth-stimulating effects of estrogen. This helps prevent endometrial hyperplasia — an overgrowth of the uterine lining that can occur when estrogen is taken without progesterone. Micronized progesterone is processed into tiny particles that improve absorption. When taken orally at bedtime, it is metabolized into allopregnanolone, a neurosteroid that may promote relaxation and improve sleep quality — a welcome side benefit for many menopausal women experiencing sleep disruption.
Side Effects
Common
- • Drowsiness or sedation (often beneficial for sleep when taken at bedtime)
- • Dizziness
- • Breast tenderness
- • Bloating
- • Mood changes
- • Headache
Serious risks and warning signs
- • Unusual vaginal bleeding — report to your provider promptly
- • Signs of blood clots (leg swelling, chest pain, shortness of breath)
- • Severe allergic reaction
- • Depression or significant mood changes
- • Jaundice or liver-related symptoms
Eligibility to Discuss With a Clinician
Progesterone is prescribed primarily to women with an intact uterus who are taking systemic estrogen therapy. Women who have had a hysterectomy generally do not need progesterone as part of their HRT regimen. Progesterone capsules contain peanut oil, so women with peanut allergies should discuss alternative progestogen options with their provider. Women with a history of blood clots, liver disease, or breast cancer should discuss risks carefully before starting.
Related Medications
Provider Reviews
Explore providers in the menopause / hrt category. This does not mean every provider offers Progesterone (Micronized); check the exact product with the provider.