Best Online Skin Treatments of 2026
Compare the best online skincare and anti-aging treatment providers. Prescription tretinoin, custom formulas, and expert dermatology consultations.
First month free — just pay $5.45 shipping
Curology
branded- ✓Custom prescription formula tailored to your skin by a licensed provider
- ✓Ingredients may include tretinoin, azelaic acid, niacinamide, and more
- ✓Plans starting at roughly $19.95/mo for a one-month supply
First bottle starting at $14.95 for new subscribers
Agency
branded- ✓Anti-aging focused sister brand of Curology
- ✓Custom prescription formulas with tretinoin, niacinamide, and more
- ✓Trial offer starting at roughly $14.95 for first-time subscribers
10% off first order when you sign up for emails
Musely
branded- ✓FaceRx custom prescription creams for melasma, dark spots, and anti-aging
- ✓Formulas may include tretinoin, hydroquinone, azelaic acid, and more
- ✓Prescription valid for 1 year with 60-day provider consultation period
First month free — just pay $5.45 shipping
Exclusive Promotion
Hers
branded- ✓Prescription anti-aging cream with tretinoin and niacinamide
- ✓Custom formula strengths based on your skin assessment
- ✓Anti-aging cream starting at roughly $35/mo
Hims
branded- ✓Anti-aging cream with prescription tretinoin, azelaic acid, and niacinamide
- ✓Dosages customized to your skin by a licensed provider
- ✓Complete anti-aging kit with cleanser, treatment, and moisturizer
Featured Provider
First month free — just pay $5.45 shipping
Curology
★ Get Started Today- ✓Custom prescription formula tailored to your skin by a licensed provider
- ✓Ingredients may include tretinoin, azelaic acid, niacinamide, and more
- ✓Plans starting at roughly $19.95/mo for a one-month supply
- ✓Free trial offer available — just pay shipping
The treatment-comparison.com difference
Researching skin care care starts with the exact product, the complete recurring cost, and the follow-up included. Use the listings below as a starting point for questions to ask a provider, not a measurement of clinical quality.
Methodology & Research
Online Skin Treatments
Online dermatology has transformed access to prescription skincare. Providers now offer custom-compounded creams, prescription tretinoin, and comprehensive anti-aging protocols — all through telehealth consultations. You upload photos of your skin, a dermatologist or provider reviews your case, and a personalized formula is shipped to your door.
Popular Skin Medications
The most prescribed online skincare ingredient is tretinoin (prescription retinoid), which has decades of clinical evidence for treating acne, fine lines, and hyperpigmentation. Many providers combine it with other actives like niacinamide, azelaic acid, or hydroquinone in custom compound formulas tailored to your specific skin concerns.
Frequently Asked Questions
Explore Other Treatment Categories
Looking for treatments in related areas? Browse our other comparison guides.