Wegovy Pill (Oral Semaglutide 25mg)
brandedFDA-approved for chronic weight management (December 2025)
Cost information
$149-$299/mo
The Wegovy pill is a once-daily semaglutide tablet that the FDA approved on December 22, 2025, and it costs $149 to $299 a month self-pay through NovoCare depending on the dose. In the OASIS 4 trial, adults on the 25 mg maintenance dose lost 13.6% of their body weight on average over 64 weeks, against 2.4% on placebo. Novo Nordisk launched it in US pharmacies on January 5, 2026, and it is also sold through telehealth services including Ro and Hims & Hers. The catch is the routine: the tablet only absorbs well if you take it first thing in the morning with a few sips of water and then wait 30 minutes before eating, drinking or taking other pills.
Dosage Format
One 25mg tablet taken daily on an empty stomach with a small sip of water
Type
Branded
Who to discuss it with
Patients who want GLP-1 therapy without injections and prefer a daily pill
Key distinction
Approved in December 2025, oral semaglutide 25mg is the first GLP-1 pill specifically approved for weight management, offering an injection-free alternative with studies suggesting approximately 16.6% weight loss.
Updated · By Treatment Comparison Editorial Team · Sources and scope
Sources: DailyMed (Novo Nordisk): Wegovy FDA label · New England Journal of Medicine (PubMed): OASIS 4 trial (NEJM 2025)
What the Wegovy pill costs without insurance
At the maintenance dose, self-pay works out to $299 a month, or $3,588 a year. For comparison, NovoCare lists the Wegovy injection at $349 a month after an introductory $199 price for the first two fills of the lowest doses. Commercially insured patients with coverage may pay as little as $25 a month with Novo Nordisk's savings offer (maximum savings $100 a month; government plan members are excluded). Novo Nordisk says it can change or end these programs at any time, so confirm the current price on NovoCare.
Telehealth services may add their own fees. Hims & Hers, for example, bills a weight-loss membership separately from the medication.
| Dose | When it is used | Self-pay price per month |
|---|---|---|
| 1.5 mg | Days 1 to 30 (starting dose) | $149 |
| 4 mg | Days 31 to 60 | $199 |
| 9 mg | Days 61 to 90 | $299 |
| 25 mg | Day 91 onward (maintenance) | $299 |
Sources: DailyMed (Novo Nordisk): Wegovy FDA label · Novo Nordisk: Novo Nordisk launch release · NovoCare (Novo Nordisk): NovoCare Wegovy prices · Hims & Hers Newsroom: Hims & Hers Wegovy announcement
What OASIS 4 found
Both groups also followed a lifestyle program. Novo Nordisk also reports a 16.6% average loss (vs 2.7% on placebo) for the scenario in which everyone stayed on treatment; it describes that figure as idealized. Stomach and bowel side effects were reported by 74.0% of people on the tablet and 42.2% on placebo.
| Result at 64 weeks | Wegovy 25 mg tablet (205 people) | Placebo (102 people) |
|---|---|---|
| Average body weight change | -13.6% | -2.4% |
| Lost at least 5% | 76.3% | 31.3% |
| Lost at least 10% | 59.8% | 14.4% |
| Lost at least 15% | 47% | 5.5% |
| Lost at least 20% | 27.9% | 3.1% |
Sources: DailyMed (Novo Nordisk): Wegovy FDA label · New England Journal of Medicine (PubMed): OASIS 4 trial (NEJM 2025) · Novo Nordisk: Novo Nordisk launch release
Where to Get Wegovy Pill (Oral Semaglutide 25mg)
Novo Nordisk's January 5, 2026 launch release names Ro, LifeMD and Weight Watchers as telehealth partners, and CVS, Costco, NovoCare Pharmacy and GoodRx among other outlets. Hims & Hers added the pill on March 26, 2026. Ro's site could not be loaded on October 26, 2026, so its prices are not shown.
Hims
Hims & Hers says it offers the Wegovy pill at all doses with cash prices starting at $149 a month. Medication requires its weight-loss membership, billed separately at $39 for the first month and $149 a month after that. Check the price for your dose before you start.
From $149/mo for medication, plus a $149/mo membership
Ro
Named by Novo Nordisk as a Wegovy pill telehealth partner at launch. Confirm the medication price for each dose and any membership fee on Ro's site.
Check site
How Wegovy Pill (Oral Semaglutide 25mg) Works
Semaglutide mimics GLP-1, a gut hormone that signals fullness and slows how fast the stomach empties, which helps people eat less. A peptide like semaglutide is normally broken down in the stomach, so the tablet is made with SNAC, an ingredient that helps it absorb through the stomach wall. Even so, the label puts absorption at only about 1% to 2% of the dose, which is why the tablet dose (25 mg a day) is far higher than the weekly injection dose (2.4 mg). The label says to take it on an empty stomach in the morning with up to 4 ounces of plain water, swallow it whole, and wait at least 30 minutes before food, drink or other oral medicines. In the label's absorption studies, less water and a longer fast both raised semaglutide levels. Blood levels also vary more from person to person with the tablet than with the injection.
Side Effects
Common
- • Nausea, diarrhea, vomiting and constipation
- • Abdominal pain, bloating, burping and gas
- • Indigestion and acid reflux (GERD)
- • Headache, tiredness and dizziness
- • Dysesthesia (unusual skin sensations such as tingling or sensitivity), reported in 5% on the tablet vs 0% on placebo
- • Hair loss
- • Low blood sugar in people with type 2 diabetes
Serious risks and warning signs
- • Boxed warning: thyroid C-cell tumors seen in rodents; human relevance is not known. Do not use with a personal or family history of medullary thyroid carcinoma or MEN 2.
- • Acute pancreatitis: stop and seek care for severe stomach pain that may spread to the back
- • Gallbladder disease, including gallstones
- • Acute kidney injury from fluid loss due to vomiting or diarrhea
- • Severe stomach and bowel side effects (2% on the tablet vs 0% on placebo); not recommended with severe gastroparesis
- • Serious allergic reactions
- • Worsening diabetic eye disease in people with type 2 diabetes, a faster heart rate, and a risk of inhaling stomach contents during anesthesia or deep sedation
Eligibility to Discuss With a Clinician
The label covers adults with obesity, or with overweight plus at least one weight-related condition, used alongside a reduced-calorie diet and more physical activity. OASIS 4 enrolled adults without diabetes with a BMI of 30 or more, or 27 or more with an obesity-related complication. The tablet is not for people with a personal or family history of medullary thyroid carcinoma or MEN 2, or a past serious allergy to semaglutide, and it should not be combined with other semaglutide products (such as Ozempic or Rybelsus) or other GLP-1 medicines. The label advises against breastfeeding while taking it. If you take levothyroxine, tell your clinician: in a label study, thyroid hormone exposure rose 33% when taken with oral semaglutide.
Related Medications
Provider Reviews
Explore providers in the weight loss category. This does not mean every provider offers Wegovy Pill (Oral Semaglutide 25mg); check the exact product with the provider.
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Frequently Asked Questions
Sources and editorial notes
Dosing, warnings, side effects and absorption facts come from the Wegovy FDA label on DailyMed (revised June 2026), and outcome figures from the OASIS 4 trial in the New England Journal of Medicine and the label, all opened October 26, 2026. Self-pay prices come from NovoCare and the Hims & Hers newsroom the same day. We did not order the medicine or verify a personalized price, and no clinician review is claimed.
Content updated . Source checking is editorial work; it is not a clinical review.
- DailyMed (Novo Nordisk): WEGOVY (semaglutide) injection and WEGOVY (semaglutide) tablets prescribing information, revised June 2026Medical or regulatory reference · Accessed 2026-10-26
- New England Journal of Medicine (PubMed): Wharton S, et al. Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity. N Engl J Med. 2025;393(11):1077-1087Medical or regulatory reference · Accessed 2026-10-26
- Novo Nordisk: Novo Nordisk's Wegovy pill, the first and only oral GLP-1 for weight loss in adults, now broadly available across America (January 5, 2026)Provider-reported product information · Accessed 2026-10-26
- NovoCare (Novo Nordisk): Price your WegovyProvider-reported product information · Accessed 2026-10-26
- Hims & Hers Newsroom: Wegovy pill and Wegovy pen now available with Hims & Hers (March 26, 2026)Provider-reported product information · Accessed 2026-10-26