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Avanafil (Stendra)
genericFDA-approved. Generic avanafil now available (Camber Pharmaceuticals)
Est. Cost
$10-$70/dose
/month
Avanafil, sold under the brand name Stendra, is the most recently approved PDE5 inhibitor for erectile dysfunction. Its primary differentiator is speed: it may begin working in as little as 15 minutes, making it the fastest-acting FDA-approved oral ED treatment currently available. A generic version from Camber Pharmaceuticals is now available in the US, which may bring costs down from the brand price of ~$70/dose to approximately $10-$20/dose with a coupon. However, it is still not widely offered through major telehealth platforms at this time.
Dosage Format
50mg, 100mg, or 200mg taken as needed, approximately 15-30 minutes before sexual activity. Should not exceed one dose per day.
Type
Generic
Best For
Men who want the fastest possible onset of action and are willing to pay a premium
Key Benefit
Avanafil is the newest PDE5 inhibitor and may work in as little as 15 minutes — the fastest onset of any FDA-approved oral ED medication.
How Avanafil (Stendra) Works
Avanafil works through the same PDE5 inhibition mechanism as sildenafil, tadalafil, and vardenafil. It may help increase blood flow to the penis by allowing cGMP to accumulate in smooth muscle tissue during sexual stimulation. What distinguishes avanafil is its selectivity for the PDE5 enzyme, which some research suggests may contribute to its faster onset and potentially fewer side effects compared to older PDE5 inhibitors. Effects typically last around 6 hours.
Side Effects
Common
- • Headache
- • Facial flushing
- • Nasal congestion
- • Back pain
Serious (Rare)
- • Priapism (an erection lasting more than 4 hours) — seek emergency care
- • Sudden vision changes or loss
- • Sudden hearing changes or loss
- • Chest pain or irregular heartbeat
- • Severe dizziness
Who Is Eligible
Avanafil is prescribed to adult men with ED. Like other PDE5 inhibitors, it is contraindicated with nitrate medications and should be used with caution alongside alpha-blockers. Men with significant cardiovascular conditions should consult a provider before use. With generic now available, out-of-pocket costs may be lower than the brand-name Stendra price, though insurance coverage may still vary.